This page tracks new and upcoming treatment options for postural orthostatic tachycardia syndrome (POTS). What’s in development? What’s promising? What’s available soon? Current topics include GSK-126, EZH2 inhibitors, IVIG, ivabradine, moxonidine, pyridostigmine, albumin, propranolol, and more. Jump to section: News, Research, Clinical Trials
Last updated: 4 years ago
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News
- AWARENESS: Man whose POTS symptoms were dismissed as ‘anxiety’ for years Sep 1, 2020
- Researchers identify promising drug compound called GSK-126 that could be a potential treatment for POTS Jun 8, 2020
- Drug [GSK-126] discovered for Postural Orthostatic Tachycardia Syndrome (POTS) Mar 9, 2020
- Monash University researchers have revealed a novel therapy that corrects the mechanism in the body that’s gone wrong in Postural Orthostatic Tachycardia Syndrome (POTS) Mar 4, 2020
- UPDATE: new website for Ehlers-Danlos syndromes (EDS) treatment and research updates Feb 15, 2020
- Stories from people with POTS pour in after Summer Dashe announces illness Dec 11, 2019
- Summer Dashe’s POTS illness isn’t rare, just take it from the thousands who wrote in Dec 4, 2019
- The article I wish I’d had: Diagnosed with POTS and still anchoring the news Nov 13, 2019
- AWARENESS: You Don’t Look Sick: ‘You might think I look better but I still feel horrible every day’ [postural orthostatic tachycardia syndrome (PoTS)] Oct 27, 2019
- Woman’s mysterious condition caused her to faint multiple times a day: Doctors thought ‘it was all in my head’ Sep 27, 2019
- New research strongly suggests postural orthostatic tachycardia syndrome, or POTS, is an autoimmune disorder Sep 9, 2019
- Research in astronauts sheds light on rare fainting disorder Aug 13, 2019
- Brigham employee battles POTS disorder to run BAA 10K Jun 22, 2019
- Effects of Rapid Water Drinking on Postural Orthostatic Tachycardia Syndrome Jun 7, 2019
- Former Packers G.M. Ted Thompson diagnosed with autonomic disorder [POTS] May 8, 2019
- Photographer shares struggle with hidden illness Jan 28, 2019
- Told symptoms ‘all in her head,’ woman raises awareness about group of rare disorders Nov 2, 2018
- What is POTS? Medford walk to benefit research on little-known disorder Oct 19, 2018
- A doctor said it was all in her head, but it was ‘the most common condition you’ve never heard of’ Jun 26, 2018
- This Mysterious Blood-Flow Disorder Is Often Misdiagnosed As Depression Jun 26, 2018
- In the Pipeline-Postural Orthostatic Tachycardia Syndrome Researchers Find High Prevalence of Autoantibodies in POTS Apr 5, 2018
Research
- A Pilot Study using the Compensatory Reserve Index to evaluate individuals with Postural Orthostatic Tachycardia syndrome Sep 30, 2020
- Daily Life Experiences: Challenges, Strategies, and Implications for Therapy in Postural Tachycardia Syndrome (POTS) Sep 26, 2020
- Treatment of Postural Orthostatic Tachycardia Syndrome With Medication: A Systematic Review Aug 24, 2020
- Postural Tachycardia Syndrome: Nutrition Implications Aug 18, 2020
- Functional gastrointestinal disorders are increased in joint hypermobility-related disorders with concomitant postural orthostatic tachycardia syndrome Aug 16, 2020
- Circadian rhythms of blood pressure and rate pressure product in children with postural tachycardia syndrome Aug 14, 2020
- Co-Segregation of Postural Orthostatic Tachycardia Syndrome, Hypermobile Ehlers-Danlos Syndrome and Mast Cell Activation Syndrome Aug 13, 2020
- Time Course of Autonomic Symptoms in Postural Orthostatic Tachycardia Syndrome (POTS) Patients: Two-Year Follow-Up Results Aug 13, 2020
- Pelvic venous insufficiency in patients with postural orthostatic tachycardia syndrome Aug 5, 2020
- Differential diagnosis of orthostatic hypotension Aug 1, 2020
- Serum Activity Against G Protein-Coupled Receptors and Severity of Orthostatic Symptoms in Postural Orthostatic Tachycardia Syndrome Jul 30, 2020
- The Preponderance of Initial Orthostatic Hypotension in Postural Tachycardia Syndrome Jul 23, 2020
- Splanchnic Venous Compression Enhances the Effects of ß-Blockade in the Treatment of Postural Tachycardia Syndrome Jul 16, 2020
- Short-term efficacy of ORS formulation and propranolol regimen in children with POTS Jul 7, 2020
- Bupropion in the treatment of postural orthostatic tachycardia syndrome (POTS): a single-center experience Jul 1, 2020
- Non-Pharmacological and Pharmacological Management of Cardiac Dysautonomia Syndromes Jun 30, 2020
- Lack of Evidence to Support Increased Salt For Orthostatic Intolerance Syndromes: A Systematic Review and Meta-Analysis Jun 26, 2020
- Normal autonomic neurophysiology of postural orthostatic tachycardia and recommended physiological assessments in postural orthostatic tachycardia syndrome Jun 26, 2020
- Cerebral Blood Flow Is Reduced in Severe ME/CFS Patients During Mild Orthostatic Stress Testing: implications for evaluation and treatment Jun 13, 2020
- Update of Individualized Treatment Strategies for Postural Orthostatic Tachycardia Syndrome in Children Jun 11, 2020
- Attention and executive function are impaired during active standing in postural tachycardia syndrome Jun 5, 2020
- Ivabradine in children with postural orthostatic tachycardia syndrome: 67% of children treated with ivabradine report an improvement in symptoms Jun 5, 2020
- Psychological correlates of patients with postural orthostatic tachycardia syndrome (POTS) Jun 5, 2020
- A New Insight on Postural Tachycardia Syndrome in Adults With Hypermobile Ehlers-Danlos Syndrome/hypermobility Spectrum Disorder May 20, 2020
- Latest Developments in Individualized Treatment of Vasovagal Syncope and Postural Tachycardia Syndrome in Children and Adolescents: An Update May 4, 2020
- Ivabradine in Postural Orthostatic Tachycardia Syndrome: A Review of the Literature Apr 28, 2020
- Proteomic analysis reveals sex-specific biomarker signature in postural orthostatic tachycardia syndrome Apr 22, 2020
- Postural Orthostatic Tachycardia Syndrome (POTS): A critical assessment of the issues regarding the pathophysiology and diagnosis of POTS Mar 25, 2020
- Targeting Treatment Refractory NET by EZH2 Inhibition in Postural Tachycardia Syndrome Mar 3, 2020
- Family history of associated disorders in patients with postural tachycardia syndrome Feb 3, 2020
- ST-segment changes during tilt-table testing in postural tachycardia syndrome: are they relevant? Jan 21, 2020
- High Submaximal Exercise Heart Rate Impacts Exercise Intolerance in the Postural Orthostatic Tachycardia Syndrome Jan 15, 2020
- When Sinus Tachycardia Becomes Too Much: Negative Effects of Excessive Upright Tachycardia on Cardiac Output in Vasovagal Syncope, Postural Tachycardia Syndrome, and Inappropriate Sinus Tachycardia Jan 15, 2020
- Prevalence of hypermobile Ehlers-Danlos syndrome in postural orthostatic tachycardia syndrome Jan 10, 2020
- Pubertal Hormonal Changes and the Autonomic Nervous System: Potential Role in Pediatric Orthostatic Intolerance Nov 12, 2019
- Plasma Exchange Therapy in Postural Tachycardia Syndrome: A Novel Long-term Approach? Nov 9, 2019
- Efficacy of β-Blockers on Postural Tachycardia Syndrome in Children and Adolescents: effective in treating POTS, alleviating orthostatic intolerance, and improving hemodynamic abnormalities Nov 7, 2019
- Pain Management In Pediatric Patients With Postural Orthostatic Tachycardia Syndrome: Current Insights Oct 31, 2019
- Adrenergic Autoantibody-Induced Postural Tachycardia Syndrome in Rabbits Sep 24, 2019
- Postural Orthostatic Tachycardia Syndrome: Mechanisms and New Therapies Aug 14, 2019
- The Benefits of Oral Rehydration on Orthostatic Intolerance in Children with Postural Tachycardia Syndrome Aug 9, 2019
- The Relationship Between Hypermobile Ehlers-Danlos Syndrome (hEDS), Postural Orthostatic Tachycardia Syndrome (POTS), and Mast Cell Activation Syndrome (MCAS) Jul 2, 2019
- Long-Term Outcomes of Children and Adolescents With Postural Tachycardia Syndrome After Conventional Treatment Jun 27, 2019
- A functional cell-based bioassay for assessing adrenergic autoantibody activity: POTS patients have increased α1AR-AAb and β1AR-AAb activity compared to healthy controls Jun 20, 2019
- Spontaneous Intracranial Hypotension Associated with Postural Tachycardia Syndrome May 22, 2019
- Do astronauts get postural tachycardia syndrome? And other updates on recent autonomic research May 14, 2019
- Sinus Node Sparing Novel Hybrid Approach for Treatment of Inappropriate Sinus Tachycardia/Postural Orthostatic Sinus Tachycardia With New Electrophysiological Finding Apr 23, 2019
- Is ivabradine a wonder drug for atypical POTS? Apr 20, 2019
- Orthostatic Cognitive Dysfunction in Postural Tachycardia Syndrome After Rapid Water Drinking Apr 9, 2019
- Proconvertase Furin Is Downregulated in Postural Orthostatic Tachycardia Syndrome Mar 29, 2019
- Active compression garment prevents tilt-induced orthostatic tachycardia in humans Mar 29, 2019
- Postural Orthostatic Tachycardia Syndrome: JACC Focus Seminar Mar 17, 2019
- The Face of Postural Tachycardia Syndrome – Insights from a Large Cross‐Sectional Online Community‐Based Survey Mar 12, 2019
- The face of postural tachycardia syndrome: insights into the background, clinical features and diagnostic journey of patients suffering from POTS Mar 12, 2019
- Increased prevalence of autonomic dysfunction due to postural orthostatic tachycardia syndrome in patients with eosinophilic gastrointestinal disorders Mar 10, 2019
- Autonomic uprising: the tilt table test in autonomic medicine Mar 5, 2019
- Postural orthostatic tachycardia syndrome (POTS): a common but unfamiliar syndrome Jan 1, 2019
- Low Sensitivity of Abbreviated Tilt Table Testing for Diagnosing Postural Tachycardia Syndrome in Adults With ME/CFS Nov 16, 2018
- Postural orthostatic tachycardia syndrome: clinical presentation, aetiology and management Oct 29, 2018
- Postural Orthostatic Tachycardia Syndrome and Vasospastic Angina: Therapeutic Approach to a Previously Unreported Association Oct 12, 2018
- Antenatal hydration in POTS – could technology help? Oct 10, 2018
- Hypocapnic cerebral hypoperfusion: A biomarker of orthostatic intolerance Sep 26, 2018
- Therapy for fatigue and cognitive dysfunction in postural orthostatic tachycardia syndrome Sep 10, 2018
- The gastrointestinal symptoms present in patients with postural tachycardia syndrome: A review of the literature and overview of treatment Sep 7, 2018
- Role of implantable loop recorders in patients with postural orthostatic tachycardia syndrome Jul 10, 2018
- Moving from the present to the future of Postural Tachycardia Syndrome – What we need Jul 3, 2018
- Efficacy of Therapies for Postural Tachycardia Syndrome: A Systematic Review and Meta-analysis Jun 21, 2018
- Postural Orthostatic Tachycardia Syndrome: Prevalence, Pathophysiology, and Management Jun 15, 2018
- The patient perspective: What postural orthostatic tachycardia syndrome patients want physicians to know Jun 7, 2018
- Postural orthostatic tachycardia syndrome and the potential role of mast cell activation May 4, 2018
- Autoimmunity in postural orthostatic tachycardia syndrome: Current understanding Apr 26, 2018
- Orthostatic intolerance and postural tachycardia syndrome: new insights into pathophysiology and treatment Apr 25, 2018
- Autoimmune postural orthostatic tachycardia syndrome Feb 28, 2018
- Managing fatigue in postural tachycardia syndrome (PoTS): The Newcastle approach Feb 22, 2018
- Successful treatment of postural orthostatic tachycardia and mast cell activation syndromes using naltrexone, immunoglobulin and antibiotic treatment Jan 11, 2018
Clinical Trials
- IVIG (Gamunex-C) Treatment Study for POTS (postural orthostatic tachycardia syndrome) Subjects May 20, 2020
- Hypercapnia and Orthostatic Tolerance in Postural Orthostatic Tachycardia Syndrome Apr 24, 2020
- Modafinil and Cognitive Function in POTS Feb 7, 2020
- Autonomic Determinants of POTS – Pilot 2 Oct 28, 2019
- Hemodynamic Effects of Compression in POTS Sep 30, 2019
- Autonomic Determinants of POTS: Effects of Moxonidine on the Symptoms of Postural Orthostatic Tachycardia Syndrome (POTS) Sep 10, 2019
- Vagus Nerve Stimulation in Treatment of Postural Orthostatic Tachycardia Syndrome Apr 29, 2019
- Adrenocorticotropic Hormone Stimulation in Postural Orthostatic Tachycardia Syndrome (POTS) Apr 5, 2019
- Dietary Sodium’s Effect on Urinary Sodium and Dopamine Excretion in Patients With Postural Tachycardia Syndrome Apr 5, 2019
- Effect of Dietary Sodium Intake on Vascular Endothelium in Patients with Postural Orthostatic Tachycardia Syndrome (POTS) Apr 5, 2019
- A Study of Pyridostigmine in Postural Tachycardia Syndrome Mar 6, 2019
- Transdermal Vagal Stimulation for POTS Feb 22, 2019
- Alterations of Attention in POTS Depending on Body Position and Hydration Feb 21, 2019
- Treatment of Orthostatic Intolerance Feb 8, 2019
- Vagal Stimulation in POTS Feb 4, 2019
- Autoimmune Basis for Postural Tachycardia Syndrome Jan 30, 2019
- Reducing Orthostatic Intolerance With Oral Rehydration in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients Jan 15, 2019
- Cardiovagal Baroreflex Deficits Impair Neurovascular Coupling and Cognition in POTS Jan 14, 2019
- Northera Improves Postural Tachycardia Syndrome (POTS) and Postural Vasovagal Syncope (VVS) Jan 14, 2019
- Breathing Device in Postural Orthostatic Tachycardia Syndrome (POTS) Jan 10, 2019
- Effect of Ivabradine on Patients With Postural Orthostatic Tachycardia Syndrome (POTS) Oct 24, 2018
- A Study to Systematically Assess the Efficacy and Safety of Intravenous Albumin Infusions in Severe POTS Aug 28, 2018
- Hemodynamic Effects of Compression in POTS Jul 27, 2018